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An appropriate ROS concentration is conducive to normal angiogenesis and vascular homeostasis, while a high concentration of ROS chronically induces ferroptosis and consequently causes pathological damage to blood vessels

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10.1016/S0002-9440(10)63847-3

In addition, NRF2 can also regulate the transcriptional expression of metabolites involved in intermediate metabolism, some of which play essential roles in the regeneration of NADPH, a key electron donor needed to reduce oxidative substrates [108]

[Abstract] In Vivo Efficacy Study RT-PCR Cell Imaging/Staining WB 2D/3D Cell Culture and Differentiation All Endogenous Metabolite Isoforms More Biological Activity melatonin receptor and inhibit PANoptosis