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Systems pharmacology modeling identifies a novel treatment strategy for bortezomib-Induced neuropathic pain

We simulated the effect of joint CLP257 and L838,417 administrations under the assumption each drugs works on a distinct effector namely KCC2 activity for CLP257 and g inh for L838,417

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Hinshelwood MM, Michael MD, Sun T, Simpson ER

These models are visually categorized by type and mechanism in Figure 6, which highlights their common outcome: ovarian dysfunction driven by oxidative stress