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Other reactions warranting urgent GP contact include: Unexplained muscle weakness or cramping Persistent vomiting or severe abdominal pain Signs of hypokalaemia (low potassium) during initial treatmentmuscle weakness, irregular heartbeat, or severe fatigue In patients with severe, longstanding B12 deficiency, rapid correction can occasionally precipitate hypokalaemia as new red blood cells are produced, consuming available potassium

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Insight into the preclinical phase of these diseases holds promise for identifying windows of opportunity for early intervention and implementing disease-modifying strategies aimed at arresting or slowing disease progression.The mechanisms of neurodegeneration discussed above indicate the clear therapeutic potential of VEGF in incurable neurodegenerative diseases (Korn 2008)

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The exercise-induced increase in BDNF production complements the neurotrophic effects of peptides like Semax