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Because women naturally maintain higher body fat percentages and respond differently to growth hormone signaling, the visible changes tend to be softer and slower

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In the Phase 1b trial of higher doses (9 mg and 10 mg), 95% of participants experienced at least one adverse event, but only one participant discontinued treatment due to side effects

Genetics play a role, as certain skin tones are more prone to hyperpigmentation, as does sun exposure, which can exacerbate the phenomenon

CMAJ 2012;184:1593-8

Whipple, Huber, and Robchett studied the effects on hemoglobin and blood regeneration of a variety of treatments, among which only raw liver showed real promise