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Anti Histones Antibodies, Serum #CantSleep Follow physician instructions if fastingSerum Anti Histone Antibodies, Serum Test Overview: The Anti Histone Antibodies, Serum test is used to detect antibodies directed against histone proteins, which are essential components of cell nuclei. The presence of these antibodies is commonly associated with drug induced lupus erythematosus (DILE) and may also be seen in certain autoimmune disorders. Why is this Test Done? Helps diagnose drug induced lupus caused by medications such as