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The primary metabolite of nicotine is cotinine (70-80%), with small fractions of the compound being converted to nicotine-N-oxide (4%), nornicotine and 4-(3-pyridyl)-4-hydroxybutanoic acid, or being conjugated to nicotine glucuronide (Benowitz et al

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As technology advances, we may see new forms of nicotine delivery systems that build on the success of current pouches

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