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doi: 10.1016/j.pmrj.2017.02.013 240 KiyotakeEAMartinMDDetamoreMS

Patients with severe deficiency or certain health problems might need a stronger initial treatment

5-Amino-1MQs confirmed high selectivity documented not to inhibit related SAM-dependent methyltransferases or NAD+ salvage pathway enzymes makes it the most validated small-molecule NNMT research tool currently available, and ensures that experimental findings can be reliably attributed to NNMT inhibition rather than off-target effects

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And yesyou are the co-author of that plan

Stratifying HGGs by IDH mutational status and gene expression programs, we found that GAA robustly and selectively accumulates across all subgroups of Grade 4 IDH-mutant astrocytoma and GBM (Figures S2E-H)