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This study provides proof of concept for an innovative drug discovery approach targeting HIV-1 PR autoprocessing as a potential strategy to combat drug resistance

doi: 10.1016/j.alcohol.2015.11.003 146 CrewsFTBecharaRBrownLAGuidotDMMandrekarPOakSet al

Mox inhibits oxidative damage by upregulating NRF2-dependent antioxidant enzymes and producing GSH, which has been shown to be the main ATMs for lean AT (64, 138)

ACS Omega 7 (29), 2533725345

doi: 10.3389/fimmu.2022.864817 Received 28 January 2022 Accepted 09 March 2022 Published 31 March 2022 Volume 13 - 2022 Edited by Bruno Rivas-Santiago, Unidad de Investigacin Biomdica de Zacatecas (IMSS), Mexico Reviewed by Katrin Doris Mayer-Barber, National Institutes of Health (NIH), United States

This is particularly significant because ARF family GTPases require complete folding to bury their myristoylated N-terminus in a hydrophobic pocket when in the GDP-bound state in the cytosol, preventing unwanted membrane attachment until the protein is activated (GTP-bound)