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Furthermore, the advances in the techniques of analysis used to quantify cotinine might also amount to a limitation, since current techniques are very sensitive, and therefore, detect very low cotinine concentrations which would be linked to non-meaningful exposures

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It included a demographic section and a section investigating the characteristic of CH (age of onset, frequency and length of active periods, and maximum number of attacks/day in the active period) and whether patients were current, former or never smokers

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