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In perimenopausal women, E2 deficiency reduces mitochondrial Ca2+ sensitivity, impairing respiratory efficiency and energy output (127)

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The ubiquitously expressed pyruvate dehydrogenase (PDH) carries pyruvate, via pyruvate dehydrogenation and formation of acetyl Coenzyme A, into the TCA cycle in both neurons and astrocytes, but no new TCA cycle intermediate is generated by the action of this enzyme alone

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