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Generation of Pf GS HA-DD parasites for conditional knockdown For generating Pf GS HA-DD parasites, C-terminal portion of Pf GS representing 9092069 bp (without stop codon at the end) was amplified and cloned into pHADD plasmid 38 for in-frame fusion with HA and destabilization domain (DD)

Highlights Thrombosis, the blood clots in arteries/veins, poses risk of cardiovascular diseases Thrombosis also affects the pathoprogression of neurodegenerative diseases (NDDs) Endothelial dysfunction and vascular inflammation also impact the pathology of NDDs Blood coagulation and platelets also affect thrombotic complications in NDDs Antithrombotic medications can significantly alleviate the thrombosis in NDDs Rights and permissions Springer Nature or its licensor (e.g

Available Volumes: 10 mL Multi-Dose Vial 30 mL Multi-Dose Vial Purity: Sterile Laboratory Grade Molecular Formula: HO with 0.9% Benzyl Alcohol Disclaimer: For Laboratory Research Use Only (RUO)

Heterozygous carriers have an enzyme activity of about 55% of the normal mean and normal levels of glutathione [18]

These changes contribute to neuroinflammation, bloodbrain barrier (BBB) dysfunction, microglial activation, and neurotransmitter imbalances