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However, the diameter ranges with differences in the frequency of pain are not clear, since painful insertions decreasing from 63% to 31% in the 2332 G range have been reported [16] whereas other authors found no differences in injection pain when comparing needles in narrower ranges, such as 2630 G [17, 18]

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Where -GCS is the rate-limiting enzyme for the reaction and cysteine is the rate-limiting substrate for the reaction [89, 90]

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