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This deficiency can lead to various issues such as nervous problems and anaemia

After 24 h, treatment and insult were applied with media change

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Extended Half-Life and Sustained Receptor Engagement The 13-amino acid N-terminal extension and Arg3 substitution reduce IGFBP binding by 7080%, extending the effective half-life from approximately 10 minutes to 2030 hours in rodent plasma resulting in prolonged IGF-1R activation in cell culture and animal models that is not achievable with native IGF-1 or shorter analogues

Cell 168 , 960976 (2017)

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