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Mechanisms of Disease: metabolic effects of growth hormone and insulin-like growth factor 1

Yoshitani M, Fukuda S, Itoi S, et al

The presence of a catechol group in the B-ring, due to its ability to donate hydrogen, increases the formation of a relatively stable flavonoid-derived radical, which is the most important determinant of reactive oxygen and nitrogen species (RONS) inhibition (188)

But for those who need it, the 8 to 12 mg daily range corresponds to injectable doses of approximately 10 to 15 mg weekly when adjusted for sublingual bioavailability