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We then examined the impact of TXNIP on P27 transcription, finding that JQ1 reduced P27 mRNA levels, and TXNIP KO did not change this outcome (Fig

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To confirm the role of RSMC in cohesion, we performed CRISPR-Cas9-mediated knockout (KO) and only obtained heterozygous RSMC KO cells with a reduced RSMC mRNA level similar to that in RSMC KD (Fig

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