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Its natural occurrence in human plasma declines with age in physiological studies

Liu J, Li J, Wu Y, Zhao Y, Luo F, Li S, et al

10.1186/s12920-023-01756-9 308 ShererM

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Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Moreover, enzymes involved in the antioxidant pathway (for instance, thioredoxin reductase) and GSH-producing pathway (for instance, glutathione synthetase and heterodisulfide reductase subunit C) were altered when gr was deleted or overexpressed in A