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Over time, repeated exposure to nicotine leads to changes in the brains chemistry, resulting in tolerance, dependence, and withdrawal symptoms when tobacco use is discontinued

Kennedy that called for a national commission on smoking dedicated to "seeking a solution to this health problem that would interfere least with the freedom of industry or the happiness of individuals." Also affected by a study critical of cigarette smoking released by the Royal College of Physicians of London, the Kennedy administration was convinced there must be movement on the issue

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But EU rules prevented the agency from launching its own testing until the commissions investigation had concluded or the UK had left the bloc on 31 December