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This is illustrated by the actions of a curcumin derivative, Curcumin5-8, which activates AMPK and regulates autophagy to ameliorate fatty liver, and the small-molecule inhibitor EW-7197, which blocks the TGF- receptor I to mitigate fibrosis and oxidative stress via the SMAD2/3 pathway

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Patented: see www.takeda.com/en-us/patents Revised: 10/2025 PRINCIPAL DISPLAY PANEL - Kit Carton - 250 IU ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] NDC 0944-4622-01 Single-dose only For Intravenous Administration After Reconstitution Only Lyophilized powder for reconstitution ADYNOVATE and diluent preassembled in BAXJECT III system Rx Only Actual potency Takeda PRINCIPAL DISPLAY PANEL - Barrel Label - 250 IU ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] For Intravenous Administration Only ADYNOVATE and diluent preassembled in BAXJECT III system Directions for use: see package insert Rx Only IU: LOT: EXP: Takeda 6521221 PRINCIPAL DISPLAY PANEL - Blister Label - 250 IU ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated] NDC 0944-4622-02 Single-dose only 6521479 For Intravenous Administration Only ADYNOVATE and diluent preassembled in BAXJECT III system Do not open until time of use Do not use if packaging is opened or damaged Discard unused portion

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