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13 Symptoms are usually symmetrical and distal, including paresthesia, cramps, weakness, and pain

The imidazole nitrogen of the histidine side chain donates one of the three nitrogen ligands to the copper, and the position of histidine at the second residue is what enables the deprotonated amide nitrogen of the preceding Gly-His peptide bond to also coordinate the copper

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The choice between medications should consider individual tolerance, weight loss efficacy, and other factors