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The process begins with the removal of a proton from the alpha-amino group of the glutamate by Asp165, resulting in the subsequent hydride transfer to the NAD+ enabled by the formation of an iminoglutarate intermediate that brings the cofactor and substrate close enough for interaction

The factors that initiate IgE production are still unclear, as are the tissues in which this occurs

Cornillie F, Shealy D, DHaens G, Geboes K, Van Assche G, Ceuppens J, et al

Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration