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These orphan nuclear receptors regulate transcriptional programs involving mitochondrial respiration, oxidative phosphorylation, fatty-acid oxidation, skeletal-muscle oxidative capacity, and metabolic adaptation

Intravenous administration in healthy adults showed excellent tolerability, with no adverse effects on cardiac, hepatic, renal, or thyroid biomarkers at doses up to 20 mg

Gao et al., 2012, 2017

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CJC-1295 is designed to stimulate the body's production of human growth hormone (HGH), a hormone that naturally declines with age and plays a role in muscle mass, metabolism, recovery, and body composition

Because SS-31 targets cardiolipin directly, Barth syndrome is the most mechanistically precise clinical indication for elamipretide, and the clinical trial data from Barth syndrome informs dosing and safety assumptions for broader research use