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As such, any clinical use should be framed as exploratory and hypothesis generating rather than standard of care

In cell and tissue models, Epithalon upregulates telomerase activity, maintains telomere length, and modulates aging-related gene expression (p16, p21) to delay senescence

2020;48(D1):D2658

21 that utilized a similar crossover design and demonstrated a significantly smaller reduction of mean 17-item Hamilton Depression Rating Scale (HAM-D) scores for a naltrexone-plus-ketamine compared to a placebo-plus-ketamine condition at day 1 postinfusion in individuals with treatment-resistant depression ( n = 12) with a similar effect size ( d = 0.7) to that found in this study ( d = 0.6)

Li J, Zhang K, Zhang Q, Zhou X, Wen L, Ma J, et al