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doi: 10.21037/tau-20-999 5 HaoYGeHSunMGaoY

PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis

In this study, the production of mtROS is derived from low-level, sustained ROS signaling generated by reverse electron transfer (RET) following partial inhibition of ATP synthase, whereas typical IBD pathology is characterized by high levels of ROS

J.ParkD

P., Figee, M., van den Munckhof, P., Schuurman, P

The authors treated the mice with antibiotics to deplete the gut microbiota or reared them in germ-free conditions which confirmed that changes in the microbiome were responsible for the ketogenic anti-epileptic effect