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This reduces the elasticity and firmness of the skin, leading to the formation of wrinkles and loss of facial definition

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The PSM count for each protein in a specific sample was first normalized using the sum of the PSM counts for all proteins in that sample

Importantly, supplementation with melatonin not only alleviates clinical symptoms related to OP, but also inhibits GM dysbiosis, promotes the function of GM, increases SCFA levels, reduces trimethylamine N-oxide (TMAO), and preserves intestinal barrier integrity (85) ( Figure 1 )

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When administrated with a high-iron diet, the transferrin-knockout mice were susceptible to develop ferroptosis-induced liver fibrosis, which was significantly ameliorated with Fer1 treatment ( via the induction of ferroptosis in HSCs, which was mainly attributed to the upregulation of HO1 (53)