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Repeated co-treatment with antidepressants and risperidone increases BDNF mRNA and protein levels in rats

10.1016/j.taap.2018.05.026 77 LvX.LinY.ZhuX.CaiX

AGEs, advanced glycation end products

(ISBN: 978-0-07-149618-6) Keywords Cocaine Toxicology Source: Drug of abuse Mechanism of Action: CNS stimulant blocks the reuptake of catecholamines: dopamine, norepinephrine & serotonin (DAT, NET & SERT transporters) Na and K channel blocker (at slightly higher doses than those blocking reuptake of catecholamines commonly coadministered with ethanol to create cocaethylene which has a longer half-life (and prolonged high) Symptoms: CNS : Euphoria , which may be followed by anxiety & agitation Psychatric symptoms (including paranoia, psychosis & the sensation of something crawling on the skin or itchy skin) Hyperactivity & Seizures (usually self limiting

fascicularis) taught to auto-regulate nociceptive stimulation using a discrete-trial, aversive-threshold model [26]

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