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Both diarrhea and constipation generally respond to standard symptomatic management approaches, including dietary modifications and over-the-counter remedies when appropriate

Toxicol Appl Pharmacol (2017) 329:11220

This is reflected in the high mortality attributed to ischemic heart disease, stroke, and related chronic conditions in the WHO European and Arctic regions (Table 2)

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L-carnitine exerts a buffer effect that helps attenuate this accumulation