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These comparisons underscore a clear mechanism- the more cohesive and opaque the encapsulating matrix, the greater the shielding effect- and they reconcile findings across different formulations

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402,403,404 By modulating PPAR/TRPC1/TRPC6 expression or inhibiting Notch3 signaling, sildenafil effectively mitigated PASMCs proliferation and HPVR, alleviating right ventricular pressure/hypertrophy

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