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Epitalons circadian-regulatory action and NAD+s mitochondrial bioenergetic support are considered complementary mechanisms rather than overlapping ones, but combination should follow a clinical review of current medications and hepatic/renal clearance considerations

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As such, comprehensive metabolomic and proteomic analyses are crucial for advancing the understanding of these conditions in-order to identify both common, and unique, metabolic alterations that could serve as diagnostic markers or therapeutic targets

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The data were further normalized to the median value of total lipid signals