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Studies have shown that early treatment with resveratrol can significantly reduce hearing thresholds at all frequencies, and can reduce the mRNA expression levels of pro-apoptotic genes Bax and Bak, and increase the mRNA expression level of anti-apoptotic genes Bcl-2 and Bcl-xL, but there was no significant difference in hearing levels between the late treatment group and the control group [114]

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These compounds improved metabolic profiles, reduced hepatic steatosis and inflammation (e.g., lowered cytokine levels), and inhibited fibrosis by decreasing extracellular matrix deposition, highlighting CB1 blockade as a mechanism to mitigate NAFLD without central nervous system side effects (Yang et al

Vascular Endothelial Growth Factor | Rupa Health