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It can activate tumor-suppressive signaling pathways while inhibit proliferation and differentiation-related signaling pathways, ultimately induce tumor cell differentiation and increase sensitivity to DOX, result in an enhanced therapy effect

J Biol Chem 289(15):1088710899

It happens when a part of the retina called the macula is damaged

ScannevinRHChollateSJungMYShackettMPatelHBistaPet al

There is evidence that [Ca2+]i increases in glaucomatous RGCs occur in dendrites and somata (121), which might account for the increased ER stress and Ca2+-dependent signals (immediate early genes (c-fos, JNK2/3, CREB), proteases, caspases and MAP kinases) in glaucomatous RGCs

Figure 4 SLC7A11 also affects the nutrient dependence of tumor cells through glutamine backfilling and GLS dependence ( SLC7A11 and immune regulation Within the tumor microenvironment, interactions involving SLC7A11 between immune cells and tumor cells play a significant role in influencing tumor survival and proliferation