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Biochemistry 46, 90419049

Abbreviations AsA: Ascorbate APX: Ascorbate peroxidase BCAT-like1: Branched chain aminotransferase proteins like 1 BLASTP: Protein Basic Local Alignment Search Tool CDNB: 1chlopro2,4dinitrobenzene DEGs: Differently expressed genes DEMs: Differently expressed metabolites DHAR: Dehydroascorbate reductase DRTS: Bifunctional dihydrofolate reductase-thymidylate EC: Enzyme Nomenclature folC: Dihydrofolate synthase G6PD: Glucose 6-phosphate dehydrogenase GMPS: Nucleotide guanosine 5-monophosphate synthase GO: Gene Ontology GPX: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSSG: Oxidized glutathione GST: Glutathione S-transferase KEGG: Kyoto Encyclopedia of Genes and Genomes LED: Light-emitting diode NCBI: National Center for Biotechnology Information NADP+: Dependent isocitrate dehydrogenase NADPH: Nicotinamide ademine dinucleotidephosphate ROS: Reactive oxygen species Spe: Spermidine SpeE: Spermidine synthase UV-C: Ultraviolet-C References Chasseaud L

for mechanistic isolation, the choice depends on which pathway is being studied

Matejuk A, Ransohoff RM

4 Ivermectin functions as a gamma-aminobutyric acid (GABA) agonist but does not readily cross the blood-brain barrier in humans, ensuring a good safety profile

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