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We show that a similar pattern occurs with transcripts involved in phototransduction (Figure 5)

While early open-label and phase 2 trials suggested potential benefits of arbaclofen in children with ASD, subsequent phase 3 randomized controlled trials failed to demonstrate significant efficacy over placebo on primary outcomes, despite favorable safety and tolerability profiles

1 Introduction 1.1 Literature review methodology This review was conducted by searching PubMed, Scopus, and Google Scholar databases using the keywords Parkinsons disease, -synuclein, dopaminergic neurons, LRRK2, mitochondrial dysfunction, comorbidities, levodopa, and neuroinflammation. Studies published in English between 2000 and 2025 were included

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The DN group had diminished body weight, significantly higher PGLs, and the nociceptive-threshold of thermal hyperalgesia and mechanical allodynia were significantly lower compared to the saline-group, indicating the development of DN

The remaining 90% are bacterial cells