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Inhibition of Schistosoma mansoni thioredoxin glutathione reductase by auranofin: Structural and kinetic aspects

In vitro studies of the hemoglobin auto-oxidation revealed that the reaction is slow ( k = 0.0115 h 1 ) under normoxic conditions (Nagababu et al., 2002), but is facilitated dramatically upon partial deoxygenation (Abugo and Rifkind, 1994) and is maximal at pO 2 of 1.33 kPa (Rifkind et al., 2004)

Any references to senescence, cellular aging, or regeneration are included strictly for literature indexing and experimental context

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A neurologist can perform nerve conduction studies, order appropriate blood work, and potentially perform a skin biopsy to establish an objective baseline against which to measure changes