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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress

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10.4174/astr.2022.102.1.29 26 PatnaikR.VargheseR.Al-KabaniA.JannatiS.BanerjeeY

Ammonia uptake by CAFs also reduces mitochondrial viability

Se supplementation in mice conferred a switch in macrophage phenotype from the pro-inflammatory M1 to the anti-inflammatory M2 subtype following lipopolysaccharide (LPS) exposure [65]

Proline-rich protein 11 silencing inhibits hepatocellular carcinoma growth and epithelial-mesenchymal transition through -catenin signaling