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Diabetes 50 : 11101118 Yakar S et al

Demethylation of caffeine results in the formation of theophylline (1,3-dimethylxanthine), theobromine (3,7-dimethylxanthine), and paraxanthine

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Importantly, ACE also demonstrated superior inhibitory effects in colorectal tumor organoids versus at the cellular level, underscoring its potential for clinical application

It is initiated by the activation of inflammasomes, which activate inflammatory caspases (such as caspase-1, -4, -5, and -11), leading to cleavage of Gasdermin D (GSDMD)