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Purity and concentration were assessed by measurement of the A260/280 ratios using a Nanodrop (Thermo Scientific, Nanodrop Products, Wilmington, DE) instrument and samples with values of 1.8 to 2.0 were processed

[19] Steiber A, Kerner J, Hoppel CL.Mol Aspects Med

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Consistently, the therapeutic effect reported for the distinct histone deacetylase inhibitors tested, which are expected to activate transcriptional activity in cells, is highly variable among different SCA3 models [118, 120, 123,124,125,126]