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(1981) 50 F 77 mg/m 3 6 h/day, 5 days/week 103 weeks (treated) 307 mg/m 3 6 h/day, 5 days/week 90 weeks 50 M,F 104 weeks (control) Rat 50 M 77 mg/m 3 6 h/day, 5 days/week 103 weeks NTP (1982) (Fisher-344) (treated) 307 mg/m 3 6 h/day, 5 days/week 88 weeks 50 F 77 mg/m 3 6 h/day, 5 days/week 103 weeks (treated) 307 mg/m 3 6 h/day, 5 days/week 90 weeks 50 M,F (control) Rat 48 M,F disulfiram f (0.05% in diet) 18 months Wong et (Sprague- (treated) EDB (119-167 mg/m 3 TWA b ) al

Biliary excretion of excess iron in mice requires hepatocyte iron import by Slc39a14

10.1016/j.phytochem.2006.05.012 Phytochemistry 17 BuetlerT

Some of the more common side effects are nausea, vomiting, diarrhoea, constipation, belching, and indigestion

Reducing them through a mechanism with a favorable safety profile is the core rationale for longevity microdosing