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Konopaske GT, Dorph-Petersen K-A, Sweet RA, Pierri JN, Zhang W, Sampson AR, et al

4.2 Circadian disruptiondriven metabolic insufficiency and Treg functional decline Circadian rhythms, the intrinsic 24-hour biological cycles, profoundly influence immune system function, including the regulation of Tregs, which are essential in maintaining immune tolerance and preventing autoimmunity such as uveitis

However, challenges including compositional variability, extraction efficiency, safety evaluation, and standardization remain key barriers to their large scale utilization

Safety and toxicity concerns present major challenges for the global ADC market, as potent cytotoxic agents can lead to severe side effects, including blood disorders and organ-specific toxicities

The QTRAP 5500 was operated in negative-ionization mode using scheduled multiple reaction monitoring coupled with information-dependent acquisition

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