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doi: 10.1038/s41467-020-16935-w 274 TiefK.SchmidtA.BeermannF

Mori, "The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure," J

Available: Accessed October 31, 2025

352 Additionally, research has shown that elevated uric acid levels inhibit insulin-induced glucose uptake in cardiomyocytes

For example, GLUT1 provides a basal, sustained, and high-rate of glucose uptake, serving as the primary transporter to meet the basic energetic and biosynthetic demands of cancer cells

These genetic abnormalities cause changes in protein structures, dynamic and expression levels, which in turn alter the cellular metabolism of the cancer cells [3]