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doi: 10.1086/381972 38 PatraS

Improves sleep quality due to an increase in melatonin

A pre-bed dose is timed to reinforce that natural nocturnal pulse, which is why the pre-bed slot is the one most consistently kept even in a once-daily schedule

The authors reveal that Ca2+-dependent ER luminal reduction is sensitive to GSH synthesis inhibition or cytosolic GSH dilution, indicating a glutathione-centered mechanism