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As discussed in this review, increased recognition of the important role of metabolic reprogramming in the pathophysiology of GBM has highlighted new opportunities to exploit the tumors bioenergetics as potential treatment vulnerabilities

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The glutaminederived metabolite KG has been implicated in modulating cellular histone and DNA methylation levels

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CD44 targets Na(+)/H(+) exchanger 1 to mediate MDA-MB-231 cells metastasis via the regulation of ERK1/2

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50 Furthermore, abnormal VEGF levels impair angiogenesis and lymphangiogenesis, contributing to renal vascular dysfunction, 51 whereas lymphatic dysfunction exacerbates interstitial edema and fibrosis

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