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Preclinical studies indicate that senescent cell burden is low in young rodents and increases with chronological age in several tissues (33, 34)

DOI: 10.1038/s41467-020-14629-x Assefa B et al

Lithium pharmacokinetics are strongly influenced by sodium and fluid intake, such that abrupt dietary sodium restriction or dehydration may increase the risk of lithium toxicity

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The previously mentioned representative antioxidants, while playing an antioxidant role, are also nutrients needed by humans and can indirectly improve the state of malnutrition in the older population, further affecting immune function and playing a preventive role (65)