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Patients are advised to check the MHRA website for current safety alerts

1991 Mar;53(3):695-7

Wattjes, M.P.,

There is absolute chance of presence of undesirable particles or endotoxins in solution, so sterile filter is used in pharmaceutical industry to get rid of all of them

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If density declines significantly, interventions include calcium and vitamin D optimization, weight-bearing exercise, and sometimes pharmacologic therapy