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Histological processing of oral cancer and normal tissue biopsies Small OSCC and normal oral (NO) tissue biopsies (measuring 34 mm in thickness) were obtained in 10% neutral buffered formalin (pH 7.5) and preserved at room temperature for 24 h

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While this does not establish a direct causal role, the elevated CE levels are consistent with the observed superiority of HDL known to be CE-rich as a mediator of ferroptosis protection

The ECM of untreated tumors is thought to be a hard microenvironment, whereas a soft ECM enhances drug resistance by increasing NF-B signaling activity and downregulating pro-apoptotic JNK signaling activity