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There are several experimental options to prevent or manage pemetrexed-related toxicity, such as the use of standard folinic acid, hemodialysis, antidotes such as thymidine, hypoxanthine, and glucarpidase, and the use of therapeutic drug monitoring

HGF binds to its specific receptor, c-Met, which is located on the surface of hepatocytes, in a paracrine or autocrine manner

Prolonged incubation of E

A mutation in the PNPLA3 gene, which produces adiponutrin, is a key genetic risk factor65

Front Mol Biosci 10:1161486 Williams T, Joseph B, Beier D, Goebel W, Kuhn M (2005) Response regulator DegU of Listeria monocytogenes regulates the expression of flagella-specific genes

El desarrollo de la artritis reumatoide se basa en una predisposicin gentica, como los alelos HLA-DR4, que crean anticuerpos contra las protenas citrulinadas, y en factores desencadenantes ambientales, como las infecciones o el tabaquismo [8]