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In this context, treatment with the gamma secretase inhibitor DAPT in MELAS organoids demonstrated the ability to reverse neurodevelopmental and neurite outgrowth defects, highlighting the potential therapeutic target of Notch signaling modulation to ameliorate neurodevelopmental deficits associated with the disease

Leopold & Langbein, 1966

This differs from aspirin, which irreversibly binds to COX-1 in platelets inhibiting this enzyme for the life of the cell

Funding This work was funded by the National Natural Science Foundation of China (No

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The growth and carbon source consumption were followed over the cultivation time (Figure 6A)