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In some embodiments, the immunotherapeutic agent may be a peptide Immunosuppressive enzymes are specific agents, such as inhibitors that block the activity of Arginase (ARG) and indoleamine 2, 3-dioxygenase (IDO), an immune checkpoint protein that inhibits T cells and NK cells, which alters the catabolism of the amino acids arginine and tryptophan in the immunosuppressive tumor microenvironment