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32 To elucidate the mechanism by which ACE elevates Fe 2+ , we further determined whether ACE increased intracellular Fe 2+ by upregulating HO-1

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Dietary iron deficiency was suspected to be the cause of iron deficiency in foals (Brommer et al 2001, Fleming et al 2006)

In addition, several reports indicated that the ghrelin receptor exhibits strong ligand-independent activity 13,14,15

10.1007/s11556-009-0047-8 260 SartoriusA.HellwegR.LitzkeJ.VogtM.DormannC.VollmayrB.et al (2009)