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( Comment: A commenter stated their opinion that the burden estimate associated with the Emergency Care Access & Timeliness eCQM and eCQMs in general includes only the burden associated with the submission of data and does not include the cost or effort associated with other activities such as: education to impacted providers and staff on the impact of the measure on their workflow

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Analysis revealed that in the unbound state, all three variants were characterized by high flexibility, whereas binding to the catalytic (C) subunit of cAPK caused local folding of the N-terminal region of PKI alpha, whereas the segment around Ser59 remained highly flexible when bound to the C-subunit (Hauer et al., 1999), suggesting the fuzzy nature of the resulting PKI alpha-cAPK complex