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Nucl Acids Res 22(15):31673173

Jimenez-Villegas, J

doi:10.1021/bi00009a003

[ 62 ] Given BACH1's pivotal function in tumor metabolism, the targeted manipulation of BACH1 is of paramount significance in cancer therapy

Blocking inflammatory pathways (MAPK and iNOS) restored its levels, suggesting that glutathione and inflammation are in a very tight, mutual relationship

Its cellular efflux via volume-dependent or volume-independent pathways works to osmotically balance the excessive production of metabolic by-products